Polysubstance use is the use of more than one drug, including when two or more are taken together (intentionally or unintentionally) within a short time period. Extremely potent substances such as xylazine and fentanyl are increasingly in the drug supply and contributing to overdose and deaths in the Carolinas.
The following resources offer education for health care providers on identifying when a patient has taken xylazine or fentanyl and understanding treatment options.
Overall, SC DPH has issued the following recommendations to monitor and treat individuals exposed to xylazine. These strategies can also be useful more broadly for polysubstance use:
- Recognize the signs and symptoms of toxic effects of the substance and intervene early
- Improve detection to facilitate an effective response and report
- Educate patients and community members about the risks of using drugs that are not prescribed and purchased from a legitimate pharmacy
- Expand the provision and use of naloxone (when indicated) and overdose prevention education
- Expand and sustain processes for linking patients to treatment for substance use disorders
Sources: Increase in Overdose Deaths and Health Hazards Associated with Xylazine in South Carolina (SC DPH Advisory); Polysubstance Use Facts
Toxicity of Xylazine and How it Impacts People Who Use Drugs
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Treatment Strategies for People who Use Fentanyl
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