Online Library for
Opioid Stewardship

Welcome

CaroNova’s Online Library for Opioid Stewardship is a compilation of best practice tools and resources that have been assembled by a team of subject matter experts from across North and South Carolina.

It is intended to be used by healthcare professionals for the prevention, intervention, and treatment of opioid use disorder. These resources may not be duplicated, sold, or used for profit in any way without direct permission from the author.

Stigma is a range of negative attitudes, beliefs and behaviors that are associated with certain conditions such as addiction. Studies have shown that stigma can hinder access to appropriate Substance Use Disorder (SUD) treatment.

Strategies

Stigma reduction strategies include:

  • Using person-centered language
  • Emphasizing societal vs. individual causes of addiction
  • Incorporating solution messages
  • Using sympathetic narratives
  • Emphasizing that effective treatment exists
  • Contact-based training and education programs targeting medical students and professionals

Sources

National Academies of Science, Engineering, and Medicine; Guiding Principles for Addressing the Stigma on Opioid Addiction; The effectiveness of interventions for reducing stigma related to substance use disorders: a systematic review

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A Caring Culture in Healthcare

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Addiction Neuroscience 101

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How Addiction Hijacks the Brain

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Words Matter – Terms to Use and Avoid When Talking About Addiction

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Alternatives to opioids include non-opioid medications and non-pharmacologic approaches to managing pain.

Strategies

According to the CDC’s 2022 Clinical Practice Guideline for Prescribing Opioids for Pain:​

  • Nonopioid therapies are at least as effective as opioids for many common types of acute pain​.
  • Nonopioid therapies are preferred for subacute and chronic pain​.
  • There are options for noninvasive nonpharmacologic approaches and nonopioid medications for Acute, Subacute, and Chronic Pain​.
  • Opioid therapy is indicated in some circumstances, as described in the guidelines.

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Best Practices for Back Pain

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CDC Clinical Practice Guideline for Prescribing Opioids for Pain

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Opioid Tapering: Patient Education Video

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Patient Education & Prevention

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TIP SC Non-Drug Strategies for Non-Cancer Acute and Chronic Pain

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Experts in the Carolinas emphasize the importance of care coordination, warm handoffs, and connections to care for individuals with opioid use disorder. According to the CDC, "People with SUDs [Substance Use Disorders] often have concurrent medical or behavioral health conditions involving complex medical histories that can require the expertise of clinicians from across various specialties. Care coordination is particularly important for patients to ensure that all their medical needs are met while they are being treated for one or more SUDs."

Strategies

Individuals with opioid use disorder need connections to ongoing SUD treatments that support their recovery. Practices that can contribute to success include engaging peer support specialists; working with family and friends; prescribing naloxone; health system/community collaboration; and leveraging telehealth. Although care coordination models vary widely, common elements include an individualized plan of care with a lead provider, discharge planning from a hospital visit, continual data-sharing, and education for both providers and patients.

Sources

CDC Care Coordination in Treatment of Substance Use Disorders

Care Coordination Strategies for Patients Can Improve Substance Use Disorder Outcomes

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Buprenorphine Treatment Locator

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ED Peer Support Implementation Guide

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Implementation of a Telemedicine Program for MOUD

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Innovations in Telehealth in Mental Health and Substance Use During COVID-19

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SAMHSA Treatment Locator

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SC DAODAS Treatment Locator

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The Project Lazarus Model

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In South Carolina, opioid-involved overdose deaths rose from 876 in 2019 to 1,400 in 2020. In North Carolina, overdose deaths (all medications and drugs) rose from 3,304 in 2020 to 4,041 in 2021. Harm reduction is an approach to preventing drug-related deaths that emphasizes engaging directly with people who use drugs to prevent overdose and infectious disease transmission, improve the physical, mental, and social wellbeing of those served, and offer low-threshold options for accessing substance use disorder treatment and other health care services (SAMHSA).

Strategies

Harm reduction strategies include overdose education, counseling and referrals to treatment for infectious disease and SUD; naloxone; syringe services programs; testing drugs with fentanyl test strips; and stigma reduction.

Strategies

Harm reduction strategies include:

  • Overdose education, counseling and referrals to treatment for infectious disease and SUD
  • Distribution of opioid reversal medications (e.g., naloxone)
  • Syringe services programs that promote the use of new or sterile injection equipment for each injection
  • Reducing the stigma associated with substance use

Sources:

SC DHEC; NC DHHS; SAMHSA

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How to Use a Naloxone Kit in the Event of an Overdose (NC)

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Narcan Instructional Video (SC)

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National Harm Reduction Coalition- Harm Reduction Resources Near You

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North Carolina Naloxone Distribution Toolkit

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North Carolina’s Syringe Services Program Listing

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Reducing Harms from Injection Drug Use & OUD with Syringe Services Programs

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SC Community Naloxone Distributors

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South Carolina Naloxone Distribution Information

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U.S. drug overdose data show troubling trends and widening disparities between different groups.

Strategies

To help reduce disparities and improve equity, SAMHSA recommends the following community-informed strategies (in addition to standard treatments such as MAT/MOUD and naloxone):

  • Implement a comprehensive, holistic approach
  • Involve the community and develop multi-sectoral, diverse community partnerships
  • Increase culturally relevant public awareness
  • Employ culturally specific engagement strategies
  • Create a culturally relevant and diverse workforce

Source: The Opioid Crisis and the Black/African American Population: An Urgent Issue

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Drug Overdose Deaths Rise, Disparities Widen

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Healthcare Access and Quality as a Social Determinant of Addiction (Webinar)

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The Opioid Crisis and the Black/African American Population: An Urgent Issue

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MOUD (such as buprenorphine) is an evidence-based treatment for OUD, yet 30% of U.S. counties don't have any clinicians who can prescribe buprenorphine.

Strategies

Access to MOUD can be improved by initiating it in hospitals and other settings, such as primary care and outpatient settings. The removal of the federal X-Waiver requirement means that all practitioners who have a current DEA registration that includes Schedule III authority may now prescribe buprenorphine for Opioid Use Disorder in their practice if permitted by applicable state law.

Sources:

Gaps in NC addiction treatment disproportionately hit rural residents of color; Evidence-Based Strategies for Preventing Overdose

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Academic Detailing Brochure: Emergency Department (ED) Initiated Buprenorphine & Referral to Treatment

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ASAM National Practice Guideline – 2020 Updated Treatment Guideline for OUD

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Blueprint for Hospital Opioid Use Disorder Treatment

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Buprenorphine Algorithm/Workflow

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Buprenorphine Use in the Emergency Department Tool

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Discharge and Treatment Referral: A Guide for Patients Beginning Buprenorphine Treatment at Home, Instruction and Referral Form

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Emergency Department Buprenorphine Treatment: A Toolkit for North Carolina Hospitals

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Emergency Department-Initiated Buprenorphine for Opioid Use Disorder (EMBED)

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Medications for Opioid Use Disorder: For Healthcare and Addiction Professionals, Policymakers, Patients, and Families (TIP 63)

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Starting Buprenorphine Immediately after Reversal of Opioid Overdose

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North and South Carolina are receiving and distributing funds from nationwide settlement agreements from opioid litigation. These funds will be used to address the opioid epidemic through treatment, recovery, harm reduction, and other life-saving programs and services.

Strategies

State-specific opioid settlement strategies are provided at the links below. Additionally, throughout this Online Library for Opioid Stewardship, resources and tools that are related to or support NC or SC opioid settlement fund strategies are flagged with a special icon at the bottom of the resource description page.

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North Carolina Opioid Settlements (CORE-NC)

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SC IMPH and DAODAS- Guide to Approved Uses for Investing Opioid Settlement Funds

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Peer support workers are people who have been successful in the recovery process who help others experiencing similar situations (SAMHSA).

Strategies

The toolkits and implementation guides in this section can help health systems and communities integrate peer support specialists into opioid use disorder treatment.

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ED Peer Support Implementation Guide

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Establishing Peer Services for Overdose Response: A Toolkit for Health Departments

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Polysubstance use is the use of more than one drug, including when two or more are taken together (intentionally or unintentionally) within a short time period. Extremely potent substances such as xylazine and fentanyl are increasingly in the drug supply and contributing to overdose and deaths in the Carolinas.

Strategies

The following resources offer education for health care providers on identifying when a patient has taken xylazine or fentanyl and understanding treatment options.

Overall, SC DHEC has issued the following recommendations to monitor and treat individuals exposed to xylazine. These strategies can also be useful more broadly for polysubstance use:

  • Recognize the signs and symptoms of toxic effects of the substance and intervene early
  • Improve detection to facilitate an effective response and report
  • Educate patients and community members about the risks of using drugs that are not prescribed and purchased from a legitimate pharmacy
  • Expand the provision and use of naloxone (when indicated) and overdose prevention education
  • Expand and sustain processes for linking patients to treatment for substance use disorders

Sources: Increase in Overdose Deaths and Health Hazards Associated with Xylazine in South Carolina (SC DHEC Advisory); Polysubstance Use Facts

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Toxicity of Xylazine and How it Impacts People Who Use Drugs

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Treatment Strategies for People who Use Fentanyl

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These resources offer training and tips for clinicians who see patients with opioid use disorder.

Strategies

These resources can be incorporated into health system trainings to help any clinician better understand and treat substance use disorder.

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ASAM National Practice Guideline – 2020 Updated Treatment Guideline for OUD

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ASAM National Practice Guideline for the Treatment of OUD – Pocket Guide

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ED Opioid Treatment Pathway

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Eight Things Hospitals can do to Combat Opioid Overdoses

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Project ECHO

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SUD 101 Core Curriculum

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Safe prescribing practices can help prevent OUD and overdose by ensuring that a new opioid prescription will not contribute to cumulative opioid dosages or medication combinations that put the patient at risk for overdose.

Strategies

Safe prescribing strategies include:

  • Clinician adherence to CDC Clinical Practice Guideline for Prescribing Opioids for Pain, Standard Opioid Prescribing Schedules, and applicable laws for prescribing opioids.
  • Check the Prescription Drug Monitoring Program (PDMP) to ensure a new opioid prescription will not contribute to cumulative opioid dosages or medication combinations that put the patient at risk for overdose.
  • Academic detailing can help healthcare providers use best practices through structured visits to healthcare providers by trained professionals who can provide tailored training and technical assistance.
  • Provide patient education about opioid use and pain management when prescribing.

Explore

Calculating Total Daily Dose of Opioids for Safer Dosage: Opioid MME Conversion Chart

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CDC Clinical Practice Guideline for Prescribing Opioids for Pain

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Opioids: Patient Education Video

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Standard Opioid Prescribing Schedules Toolkit

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Opioid use disorder (OUD) is defined by the Diagnostic and Statistical Manual of Mental Disorders as a problematic pattern of opioid use leading to clinically significant impairment or distress. Effective screening and assessment tools can help clinicians identify and treat OUD.

Strategies

Multiple validated screening and assessment tools exist for use in various contexts. A useful summary table of evidence-based screening tools and assessments can be found here.

Explore

ASAM National Practice Guideline – 2020 Updated Treatment Guideline for OUD

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Clinical Opiate Withdrawal Scale

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Development and Initial Validation of the PEG, a Three-item Scale Assessing Pain Intensity and Interference

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Instrument: Drug Abuse Screening Test (DAST-10)

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Questions for Identification of Opioid Use Disorder based on DSM-5

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Screening, Brief Intervention, and Referral to Treatment (SBIRT)

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Disclaimer

CaroNova’s opioid resource library is designed to be used by health systems in North Carolina and South Carolina to accelerate adoption of best practices for opioid use disorder prevention, treatment, and recovery. The links provided by CaroNova are to publicly available resources. Although these resources are in the public domain, they should be used for educational purposes, and not for any commercial purposes. Please review the source’s restrictions, if any, on using, redistributing or reproducing their documents, toolkits and other information. CaroNova is not a healthcare provider, and the information and resource links available on this website are not intended as a substitute for individual professional medical advice, diagnosis, or treatment. I understand and accept these terms and conditions.